Private consultancy by biochemistry expert for your blood results.
Send your blood results
and your questions
Evaluate process is maximum within 3 days.
Then we will give our consultancy service and further chat communication is available.
What we doing ?
This is online and private consultancy website for biochemistry lab results.
Upon your questions over your lab results in context of biochemistry, our doctor will evaluate your blood results, gives advice to you, he might enlight any question you stuck on your results and will reply your questions. This might be beneficial for
patients in situations since many times seem contradictions between patients situation and present blood results.
Doctor might asks to you about dietary, your drugs, lifestyle, age, weight or any related specific detail related to your question that seem important for give best advice to you.
After each request of you and following answer from doctor, there would be chat interface would be opened for a limited time for further questions directly to doctor. This is beneficial for further clarification and assist.
For one enquiry fee is 50$
Maximum 3 days reply time has to be awaited for our answers.
Importance of online consultancy on lab results in context of biochemistry
Biochemistry lab results always give clues about whats going on of your health and always very useful a track tool for patients, because of this
almost all doctors of various fields use it for diagnose and always require a detailed review. The symptoms are appear in the blood results or other samples such as urine, fecal matter, skin samples so on.
Since doctors the patients are gone evaluate this results, they deduct an opinion and merge this deduction with their field expertise and experience so follows a strategy for effective a treatment.
But sometimes although their expertise in the field, they can miss the some points appear on the lab results , maybe sometimes an external effect such as a drug, infection, a genetic past in family,
lifestyle, dietary or other consumption habits might effect the same point of doctor look at results and might mislead him/her. Since such cases are frequently occur, an external view for evaluate
might helpful for the patients treatments. Because of that we setup this online and private evaluation platform by Mr. Gurel.
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Tackling the Blood Evaluations
Blood tissue is vital for the organism, serving various essential functions. It transports substrates from the external environment to tissues and removes metabolic waste, crucial for the organism's healthy function. Assessing blood through measurements is important to understand how well these functions are performed and to identify any deficiencies. Analysis of Blood Results Analytical evaluation of blood results helps us identify deficiencies within the organism via the circulatory system. This analysis enables pinpointing these deficiencies and determining the most accurate and specific external support needed by the organism. However, some blood results that appear imbalanced according to population reference ranges may actually reflect adaptations specific to the organism's needs. In such cases, what might seem like imbalance in the normal population could represent a new equilibrium established by the organism. Intervening in these imbalances could disrupt the mechanism the organism has developed to maintain balance, potentially harming the organism. Correct Treatment Approach Therefore, sometimes refraining from intervening in certain imbalances and carefully assessing them can be the most appropriate treatment approach. In this context, rather than adjusting blood results to fit specific reference ranges, analytical evaluation of blood results for interventions that support the organism is critical for therapeutic healthcare. This approach allows for determining the most suitable support and treatment methods while preserving the organism's natural balance mechanisms.
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Thermoregulation-1
Thermoreceptors are found in peripheral tissues such as the skin and internal organs and detect temperature changes. These thermoreceptors are divided into two types: warm and cold receptors. TrpV1 is sensitive to high temperatures and becomes active when the temperature rises, while TrpM8 is sensitive to low temperatures and plays a crucial role in cold perception. The signals from these thermoreceptors detecting temperature changes are transmitted to the brain through nerves. These signals reach the preoptic area in the hypothalamus. Preoptic Area and Thermoregulation: The preoptic nucleus receives and processes information from thermoreceptors. This region functions as the primary center for detecting and regulating body temperature. Stimuli from the preoptic area are transmitted to other regions of the hypothalamus, particularly to the posterior hypothalamus, which is responsible for thermoregulation. Posterior Hypothalamus and Autonomic Responses: The posterior hypothalamus plays a significant role in the execution of thermoregulation. Efferent signals from this area stimulate the sympathetic and parasympathetic nervous systems, initiating various autonomic responses. These responses include vasodilation (widening of blood vessels), vasoconstriction (narrowing of blood vessels), sweating (to lower body temperature), and shivering (to increase body temperature). Hormonal Responses: In the thermoregulation process, not only autonomic responses but also hormonal responses play an important role. When high heat is detected, signals from the preoptic area can increase the secretion of CRH (Corticotropin-Releasing Hormone). CRH triggers the release of ACTH (Adrenocorticotropic Hormone), resulting in increased cortisol secretion. When low heat is detected, the secretion of TRH (Thyrotropin-Releasing Hormone) increases. TRH stimulates the release of TSH (Thyroid Stimulating Hormone), leading to the release of thyroid hormones, which in turn increases metabolic rate and heat production.
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thermoregulation-2
Organum Vasculosum Lamina Terminalis (OVLT) is a region where the blood-brain barrier is weak. Therefore, the passage of molecules from the bloodstream into this region is easier. Sensitivity to Cytokines: OVLT is sensitive to circulating pyrogenic cytokines (IL-1, TNF, IL-6). Pyrogenic cytokines released during infection or inflammation stimulate cytokine receptors in the OVLT. This stimulation increases the production of Prostaglandin E2 (PGE2) in the OVLT. The produced PGE2 stimulates the preoptic area of the hypothalamus. The preoptic area changes the set point of body temperature to a higher level under the influence of PGE2. High Temperature Perception: The preoptic area, which changes the set point, perceives higher temperatures as normal and causes an increase in body temperature. An increase in body temperature (fever) is an important defense mechanism in fighting infections. High body temperature makes it difficult for many foreign pathogens to survive and reproduce.
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osmoregulation
The cell membrane acts as a barrier between the internal and external environments of the cell and is a selectively permeable membrane that is permeable to water molecules. An important force in the passage of water molecules across the membrane is osmotic pressure. Polar molecules, like water molecules, interact with positively and negatively charged atoms and molecules, and these interactions reduce membrane permeability. The atoms and molecules that interact most with water molecules in the blood and thus have the greatest effect in creating osmotic force are sodium ions (Na⁺), chloride ions (Cl⁻), bicarbonate ions (HCO₃⁻), urea, and glucose. Due to the concentration difference on both sides of the cell membrane, imbalances in osmotic pressure try to equalize, and during this equalization, water molecules tend to move from low concentration areas to high concentration areas. This can be defined as the Law of Diffusion and is based on the random movement of water molecules. This movement continues until the concentrations of solvent molecules equalize. If the intracellular osmotic pressure increases, water outside the cell enters the cell due to the high osmotic pressure difference. This causes the cell to swell and the cell membrane to stretch. Excessive water intake can burst the cell or cause the cell membrane to tear. This phenomenon is called "cell lysis." If the intracellular osmotic pressure decreases, the fluid inside the cell flows out, causing the cell to shrink, dry out, and impair some cellular functions. Both of these conditions are harmful to cell health, and it is necessary to maintain osmotic pressure balance for the cell's survival. Sensitive osmoreceptors are present to stabilize blood osmotic pressure within a narrow range. These osmoreceptors are found in the anterior preoptic area of the hypothalamus, the supraoptic nucleus, the Organum Vasculosum of the Lamina Terminalis (OVLT), and the Subfornical Organ (SFO). In these areas, the blood-brain barrier is weak. Osmoreceptors detect changes in blood osmolarity levels and send signals to various centers to generate physiological responses accordingly. The paraventricular nucleus (PVN) and supraoptic nucleus (SON) are centers where the synthesis and release of ADH, the most important parameter in osmotic pressure, occur. When blood osmolality increases, signals are sent to these areas to increase ADH release. When blood osmotic pressure decreases, osmoreceptors are stimulated, and aldosterone secretion is increased through both local interactions and autonomic nervous system stimulation. This increases sodium reabsorption, raising blood osmolality. Angiotensin II constricts blood vessels, increasing blood pressure and stimulating aldosterone release. It indirectly contributes to an increase in blood osmotic pressure by increasing aldosterone release. Osmoreceptors, when sensing high osmotic pressure in hypertonic conditions, trigger the feeling of thirst. In this case, the person drinks water and tries to reduce body osmolarity. The thirst center is located in the lateral preoptic area of the hypothalamus, and when osmoreceptors are stimulated by hypertonic blood, the feeling of thirst increases, trying to reduce blood osmolarity.
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Hypothalamic purinergic receptors-1
ATP (Adenosine triphosphate) molecule is the primary molecule that allows cells to store and transfer energy, and it is used in many vital biological processes. As you mentioned, the main processes in which ATP plays a role are as follows: Anabolic and catabolic reactions: It provides energy during the synthesis (anabolic) and breakdown (catabolic) of biomolecules. Synthesis of proteins, DNA, and RNA: The necessary energy for the formation of these biomolecules comes from ATP. Muscle movement: The binding and movement of actin and myosin filaments in muscle cells are possible with ATP. Ion pumps and carrier proteins in the cell membrane: The functioning of ion pumps like the Na+/K+ pump depends on ATP. Transport of organelles and vesicles along microtubules and microfilaments: In these processes, ATP activates motor proteins (such as kinesin and dynein). Protein phosphorylation: During the phosphorylation of proteins, ATP provides the phosphate group. Cellular signal transmission: ATP is used in the synthesis of second messenger molecules like cAMP. Thermoregulation: ATP plays a role in the regulation of body temperature. Cell division: ATP is used during chromosome movement and the reorganization of the cytoskeleton. Programmed cell death (apoptosis): ATP is used in energy-requiring processes during apoptosis. ATP enables cells to survive, grow, reproduce, and adapt to environmental changes. Therefore, ATP is an indispensable energy source for biological systems
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Hypothalamic purinergic receptors- 2
Regions of the brain where the blood-brain barrier is weak, such as the Median Eminence, Area Postrema, Organum Vasculosum of the Lamina Terminalis (OVLT), and Subfornical Organ (SFO), help regulate the body's homeostatic processes by transmitting information from the blood circulation to the hypothalamus. Purinergic receptors located in these regions convey data to the hypothalamus about ATP levels circulating in the blood. As a result, signals are sent to areas of the hypothalamus that play a significant role in appetite mechanisms and determining how substrates are utilized, such as the Arcuate Nucleus (Arc), Paraventricular Nucleus, Lateral Hypothalamus (LH), Ventromedial Hypothalamus (VMH), and Supraoptic Nucleus (SON). These signals lead to the activation of appropriate mechanisms based on the organism's energy status, thereby maintaining energy balance. This process is critical for maintaining the body's energy homeostasis and regulating metabolic processes.
